Green, Fast and Clean Chemistry

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The Conjure™ Flow System	The Propel™ Flow System
The Conjure is a fully automated segmented flow system. Conjure has holds up to 40 different materials for screening or library synthesis, even matrix libraries are possible. With the automated segment preparation a broad spectrum of stoichiometries can be programmed. With online LC/MS, the Conjure will sample each segment, dilute and inject into an online LC/MS. Throughput of data is as high as every 5 minutes. The Conjure also has multi-step synthesis capabilities where first stage reactions can be independently incubated from -20 to 100 °C prior to addition of second step reagents.	The Propel is a fully automated "Walk Up" segmented flow system specifically designed as a shared resource. Propel holds up to 3 reactant materials for screening, optimization and the scale up of new reaction conditions. It's programming interface enables the fast set up of up to 9 experiments, where stoichiometry, incubation rate and temperature are varied. The Propel is ideal for the development of new reaction methods when starting materials are precious. Experiments using as little as 20 µL of reactant are routinely performed. Scale up with Propel is easy. Reaction conditions screened at 20 µL are easily scaled to over a 100 grams. With optional online LC/MS, the Propel process samples as fast as every 5 minutes.

Accendo's dedicated segmented flow systems enable flow chemistry to expand beyond the limitations of continuous flow formats. With our unique automation, we enable Screening, Optimization, Reaction Kinetic Studies and Compound Libraries at scales that preserve precious starting materials and allow scale up to 100 grams. Both Conjure™ and Propel™ isolate segment preparation and incubation, which allows for higher experimental throughput, eliminates diffusion issues and broadens chemical compatibility (neat H2SO4 and HCl).

Benefits of Segmented Flow Chemistry

• Broader Chemistry Conditions
  Segmented flow chemistry systems enable extreme reaction conditions at temperatures of up to 300 °;C pressures of up to 150 bar. These conditions are more extreme than typical small scale microwave reactors and they have the added flexibility of scaleability (milligrams to 100s of grams) in the same reactor system.
• Reagent Usage
  Segmented flow chemistry eliminates the over use of precious and expensive reagents. This is specifically useful when developing new reactions (screening and optimization) as only the minimum required amount of reactant is utilized for each analytical experiment. Unlike continuous flow chemistry the amount of reactant used per experiment is independent of the reactor volume.
• Minimized Diffusion
  Segmented flow chemistry uses an immiscible solvent as a spacer that maintains a consistent concentrated segment as it progresses through the flow reactor. The dilution effects observed in continuous flow systems are nonexistent in segment flow chemistry systems. This also enables more consistent sampling of product for online analytical and preparative LC/MS.
• Experiment Throughput
  Throughput with segmented flow chemistry is dramatic all greater than that of continuous flow. Because experiments (segments) are segregated by immiscible solvent, multiple segments can be metered, mixed and injected into the flow reactor in a serial/parallel methodology. Increased throughput can be as much as a factor of 10 times that of continuous flow.
• Chemical Compatibility
  In segmented flow chemistry, the working components of the system (pumps, syringes, check valves) are never exposed to the reactant materials. Enabling the routine use of harsh reagents such as HCl and H2SO4.
• Online LC/MS
  Only Accendo Corporation's segmented flow reactors have online LC/MS interface options. Both analytical and preparative LC/MS are easily integrated. Our analytical interface option even works up the sampled segment by diluting prior to injection into the analytical system.

These systems have enabled the pursuit of faster, greener and cleaner reactions including:

The Conjure Flow Reactor System , commercialized in June 2009, is a powerful and highly automated multi-step chemical flow reactor system that automates the screening/optimization and online LC/MS analysis of hundreds of conditions. Once optimized starting materials can be scaled to gram level quantities. Automated synthesis of large and small compound libraries is fast and efficient with the Conjure's 40 reagent carousel.

The Propel Flow Reactor System , introduced in February 2010, is an automated segmented flow reactor that uses the technology developed for the Conjure but designed for a multiple user "WALK UP" environment where ease-of-use is critical. With the Propel, exploring flow reactions is simple and fast, automatically screen up to nine conditions and scale to hundreds of grams. Like the Conjure, the Propel may be optionally configured for automated online LC/MS analysis.